For a few decades, modafinil has been the global talk taking the internet by storm when it comes to cognitive-enhancing products. Google it and you’ll find amazing results about it.
It’s the world’s first safe smart drug as depicted by researchers. It’s a Food and Drug Administration (FDA) approved drug for certain health problems but people widely use it for off-label purposes. What should you know about this smart drug?
This is the ultimate truth about modafinil – its pointers on the drug benefits, its mode of action, various uses, dosage & safety, and where to buy well-tried modafinil pills from the best and safe e-pharmacy at the best cheap price with excellent shipping ever. Here we go!
What Is Modafinil?
It’s not just a drug for health treatments as doctors prescribed for certain sleep disorder conditions. The drug has another effectual use – that’s why it’s commonly dubbed as a smart drug.
Now, what is modafinil? Or what type of drug is it? It’s a drug that comes as a brand-name or generic alternatives. Just like generics, the brand-name version – Provigil® is made of modafinil as the active ingredient.
For its approval, it’s prescribed to patients with various sleep-related conditions including narcolepsy, obstructive sleep apnea, excessive daytime sleepiness, idiopathic hypersomnia, work schedule disorder, and other conditions.
Medical specialists can also prescribe modafinil pills for patients suffering from ADD/ADHD due to its ability to improve concentration, restore wakefulness & focus. Most interestingly, it’s used for off-label purposes due to its powerful effects in promoting wakefulness and improving cognition .
Let’s get to know how it becomes the best remedy for various purposes due to its benefits.
Main Benefits of Modafinil Drug
Outside of prescribed use, modafinil medication is used to improve productivity at work or school. That’s why students and executives – notably CEO’s, entrepreneurs, and creatives, and professionals among the majority of people use it. It’s a potent drug useful for long-enduring periods of work – this is also another reason why military & astronauts use it for long missions, or while performing repetitive tasks.
Does it make you smarter? Sure. It can give you an extra boost during complex work or studying. It’s the ultimate beneficial drug for studying, improving productivity, and promoting wakefulness. Most notable, individuals using modafinil can work longer on a day when taking it. Its effective elimination half-life is about 15 hours .
To most patients, modafinil is better prescribed for conditions involving excessive sleepiness.
Modafinil is also used to overcome the symptoms of ADHD by boosting dopamine concentrations in the brain.
How Does Modafinil Work?
Modafinil – an active ingredient used in various brand-name or generics functions by stimulating the release of chemicals in the brain that promote wakefulness. It acts as a wakefulness-promoting agent by stimulating some chemical substances in the brain that causes sleep disorders.
Although its exact mechanism of action is not fully understood, scientists depict that its effects are similar to sympathomimetic agents including amphetamine & methylphenidate. Modafinil pharmacology raises the number of dopamine concentrations (a chemical neurotransmitter that the brain nerves use to effectively communicate with each other) in the brain.
With this note, modafinil is not a direct or indirect-acting dopamine receptor agonist. It works by binding to the dopamine transporter & inhibits dopamine reuptake. This activity promotes wakefulness by increasing the levels of dopamine .
What If It Doesn’t Work for Me?
Now that it works for various groups of people as a remedy to sleep disorders, some people – healthy ones may try using modafinil for cognitive effects and to promote wakefulness. What if it doesn’t work?
It may not work for some users due to:
- poor quality medication – avoid this by getting it from reputable e-pharmacy;
- insufficient dose strength. A standard dose strength is 200 mg, adjust it by increasing to 300 mg, 400 mg (max) or reduce it to 100 mg or 50 mg, try this until you get the right dose strength that’s effective and tolerable;
- genetic polymorphisms (create issues with drug metabolism) – a unique variation of a particular gene. Combine modafinil with other safe supplements that work to slow down its metabolism – although it’s not recommended;
- inactivation by some compounds – interactions with other supplements/foods/medications in the gut. It’s simple to avoid this drug mix. It can be a serious health problem. Take modafinil medicine at least 1 hour apart from all the other supplements a doctor prescribed you;
- drug tolerance. It may not work if you are a long-term user. This experience is a common issue reported by individuals who take modafinil regularly. You may fix it by taking periodic breaks from this drug use. Preventing tolerance requires taking a day off per week or one or two weeks off per month.
Above all, it’s crucial to first consult with a medical specialist before taking any medicine. Do not self-medicate.
Best Way to Take Modafinil Pills Correctly
This is a medication that requires a prescription from a doctor. It’s easy to follow the right prescription if a doctor prescribes you to medicate narcolepsy. What if you using it to gain cognitive function? Or improving productivity and get more work done? First, consult with a doctor for the right dosage suitable to you.
This is how to take modafinil doses safely for studying and treating narcolepsy.
Modafinil Dosage for Studying
Although it’s an off-label use, modafinil is the ultimate “king” of the study drugs. With its impressive mechanism of action, It works through several different pathways in the brain that culminate together to boost the entire process of studying.
Safe dosage involves some strengths with its similar effects including:
- increases wakefulness;
- increases dopamine;
- alleviates fatigue;
- boosts memory;
- improves focus & concentration.
First, it’s best to use modafinil when you are well rested to ensure your brain is in optimal condition. Make sure you have eaten breakfast and pack some nutritious snacks with you to eat it throughout the day.
The best time is to take this medicine when you’re ready for studying. Take modafinil about 45 minutes earlier before a planned study task for the effects of the medicine to begin. Many students take it just before they get to their desks or workstation.
The best way to take modafinil for studying is to take the recommended dose of 200 mg. This is a common form of medicine. Some students find this too stimulating and choose to cut the pills in half. They may also opt for armodafinil version in the dose strength of 150 mg. The most common armodafinil products are Artvigil and Waklert. Students taking modafinil for the first time may opt to take lower doses and increase it depending on the drug efficacy and tolerability.
Modafinil Dosage for Narcolepsy
As a prescription, the dosage in narcolepsy is 200 mg taken a single dose once a day with or without food in the morning. This is similar to the dosage of obstructive sleep apnea (OSA). Also, a patient can increase the dose up to 400 mg maximum as it has also shown to be well-tolerated to many people but there is no consistent evidence depicting that this dose strength confers to an additional benefit.
Additionally, dosage for shift work disorder (SWD) is recommended to use modafinil 200 mg dose orally once a day as a single dose approximately one hour before starting your work shift .
For safe dosage with modafinil, the dosage adjustment in patients with severe hepatic impairment should take the lower dose of 100 mg unlike patients with normal hepatic function.
Is It Safe to Take This Medicine Every Day?
First, modafinil is generally considered safe for most people – highly tolerable with minor side effects. The long-term safety of modafinil is not well established and not known.
Unlike most psychiatric medications, modafinil’s safety in regards to negative effects does not build up over time. The medication lasting effects only last for the day (from 10-15 hours) that you take it and can safely be administered as needed or every day depending on the reason you are taking it.
This drug should only be taken once a day (in 24 hours). If you are taking modafinil to medicate narcolepsy or OSA, you will need to take it in the morning every day for a time your doctor recommends. If taking modafinil as a remedy to shift work sleep disorder, you will need to take it 1 hour before the beginning of your work shift for a longer period until you are done with the work sleep disorders that affect you.
Of most concern is whether modafinil is taken long-term. Is there any modafinil long-term negative effects? This depends on how often you take this medication.
The fact is: Modafinil is generally well-tolerated at high doses. Several in-depth studies have concluded that there is no risk of developing a tolerance for modafinil for everyday long-term use. It’s better to stop it when the symptoms you were using it for resolved .
What Are the Side Effects of Modafinil?
Although modafinil is a very safe drug dubbed as a “smart drug”, side effects cannot be fully ruled out.
The severity of side effects does not affect everyone. It varies from individual to individual due to health condition, response to medication, and adherence to modafinil as well as drug mixing resulting in interaction.
However, modafinil less serious side effects long term. It can last for a few days, hours, or minutes and fades away with continual use of medication. Its common negative effects include:
- a stuffy and runny nose;
- difficulty sleeping;
- head pain;
- anxious feelings;
Infrequent side effects that tend to have a severe expression include:
- change in vision;
- persistent sleepiness;
- memory loss;
- abnormal heart rhythm;
- an inability to empty the bladder;
- chest pain;
- lazy eye;
- mood changes;
- psychiatric symptoms;
- fast heartbeat;
- high/low blood pressure;
- throat irritation;
- serious rash (Stevens-Johnson Syndrome).
This is not a complete list. Some individuals can experience RARE negative effects that need immediate medical specialist help .
Like any medicine, interaction with food, alcohol and other meds can occur. This is the ultimate reason not to self-medicate with any drug including modafinil.
It’s very important to consult with a doctor before trying modafinil. Doctors’ advice is necessary for a safe dosage of this drug to avoid its interaction with other meds that can potentially harm your health with adverse negative effects.
Other Drugs and Alcohol
You are safe and ready to reap the beneficial effect of modafinil if you have a healthy body and keen on adhering to its dosage and contraindication.
Several medicines may interact with modafinil, such as Inderal or propranolol, Sandimmune, Cyclosporine/ Neoral, Rifampin/Rifadin, Rimactane, as well as antifungal medications.
Other medications that may cause interaction with modafinil to include:
- Phenytoin (Dilantin), carbamazepine, or phenobarbital;
- isocarboxazid, phenelzine, selegiline, rasagiline, or tranylcypromine;
- seizure medication such as carbamazepine, phenytoin, or phenobarbital;
- antidepressants such as nortriptyline (Pamelor), doxepin (Sinequan), amitriptyline (Elavil, Etrafon), imipramine (Janimine, Tofranil), and others;
- a sedative such as midazolam, diazepam, or triazolam;
- amitriptyline, imipramine, nortriptyline (Pamelor), doxepin, and others;
- an MAO inhibitor.
This is not a comprehensive list. Make sure to let a doctor give you an “OK” when mixing other drugs with modafinil. It’s however best not to combine it with certain drugs that can harm your health .
Moreover, should you avoid alcohol when taking modafinil? Ultimately, do not use alcohol while under modafinil since it is unknown how this will affect you.
Modafinil & alcohol have opposite effects on individual brain chemistry. Alcohol unexpectedly can boost the activity of the neurotransmitter – Gamma-aminobutyric acid (GABA) and reduces the action of glutamate. Any modafinil drug is a GABA antagonist that decreases GABA production and boost glutamate production.
Should I Take Modafinil with Food?
Modafinil is safe if taken with food. It comes as a tablet to be taken by mouth. It is usually taken once a day with or without food or on an empty stomach.
However, to reduce the duration of its onset of action, most people take it sublingually (by placing modafinil under the tongue), or by swallowing the tablet on an empty stomach. This allows quick absorption of the active ingredient either modafinil or armodafinil.
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- Modafinil. Retrieved: March 12, 2020. Drugs.com.
- Practical Use and Risk of Modafinil, a Novel Waking Drug. By Dongsoo Kim. Published: Feb 22, 2012. Ncbi.nlm.nih.gov.
- ‘Smart Drug’ Modafinil Actually Works, Study Shows. By Laura Geggel. Published: August 19, 2015. Livescience.com.
- Modafinil: A Review of Neurochemical Actions and Effects on Cognition. Michael J Minzenberg & Cameron S Carter. Published: 22 August 2007. Nature.com.
- Modafinil Dosage | Usual Adult Dose for Narcolepsy. By Drugs.com. Updated: on Apr 22, 2019. Drugs.com.
- Modafinil (pdf). Retrieved: March 12, 2020. Moodtreatmentcenter.com.
- Modafinil Side Effects by Likelihood and Severity. Retrieved: March 12, 2020. Webmd.com.
- Modafinil | Drug Interactions. Retrieved: March 12, 2020. Drugbank.ca.